The Indian Institute of Spices Research (IISR), Kozhikode (Calicut) a constituent body of Indian Council of Agricultural Research (ICAR) is a major Institute devoted to research on spices. In 1976, it started as a Regional Station of the Central Plantation Crops Research Institute (CPCRI), Kasaragod engaged in research on spices.
A National Research Centre for Spices was established in 1986 with its headquarters at Kozhikode, Kerala by merging the erstwhile Regional Station of CPCRI at Kozhikode and Cardamom Research Centre at Appangala, Karnataka. Realising the importance of Spices Research in India this Research Centre was upgraded to Indian Institute of Spices Research on 1st July, 1995.
The laboratories and administrative offices of the institute are located at Chelavoor (50m above MSL), 11 km from Kozhikode, Kozhikode District, Kerala on the Kozhikode-Wyanad road (NH 212) in an area of 14.3 ha.